Whether Fisher's experiment was reckless or whether it was heroic depends on how you think about science, and what risks we're willing to take in pursuit of something groundbreaking. Nancy, a patient at Fairview Developmental Center in the 1960s, before she began LSD treatment with Gary Fisher. (Courtesy of Purdue University Libraries, Virginia Kelly Karnes Archives and Special Collections/ KQED) Before treatment, Nancy spent much of her time in restraints, in order to keep her from injuring herself..

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Psychologists believe that we're wired to react more strongly to crummy happenings than pleasant ones that on the edge feeling lingers as a primitive form of self protection. And a combination of nature and nurture makes some of us moodier types. "Think of emotional resilience like an immune system," Winch says.